Longitudinal analysis of the rectal microbiome in dogs with diabetes mellitus after initiation of insulin therapy.

ABSTRACT: There have been numerous studies in humans and rodents substantiating the role of the gastrointestinal microbiome in the pathogenesis and progression of both type 1 and type 2 diabetes mellitus. Diabetes mellitus is a common endocrinopathy in dogs; however, little is known about the composition of the gut microbiome during the development and treatment of diabetes in this species. The objective of this pilot study was to characterize the gastrointestinal microbiome of dogs with diabetes mellitus at the time of diagnosis and over the first 12 weeks of insulin therapy and identify associations with glycemic control. Rectal swabs and serum for fructosamine measurement were collected from 6 newly diagnosed diabetic dogs at 2-week intervals for 12 weeks. Rectal samples were sequenced using 16S,

SUBMITTER: Laia NL 

PROVIDER: S-EPMC9447884 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature