Recombination-aware phylogeographic inference using the structured coalescent with ancestral recombination.

ABSTRACT: Movement of individuals between populations or demes is often restricted, especially between geographically isolated populations. The structured coalescent provides an elegant theoretical framework for describing how movement between populations shapes the genealogical history of sampled individuals and thereby structures genetic variation within and between populations. However, in the presence of recombination an individual may inherit different regions of their genome from different parents, resulting in a mosaic of genealogical histories across the genome, which can be represented by an Ancestral Recombination Graph (ARG). In this case, different genomic regions may have different ancestral histories and so different histories of movement between populations. Recombination therefore po

SUBMITTER: Guo F 

PROVIDER: S-EPMC9447913 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature