Predictors of High Sputum Eosinophils in Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Background

Eosinophils are involved in the development of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroid responsiveness. We evaluated clinical predictors of high sputum eosinophil levels in a COPD cohort in China.

Methods

We conducted an observational, prospective, population-based, cross-sectional study. Participants were tested for COPD and underwent spirometry, computed tomography scans, and a blood test. Participants also produced induced sputum and responded to an information-gathering questionnaire. High sputum eosinophils were defined as ≥3.0%. Multivariate logistic regression was used to identify predictors of high sputum eosinophil levels.

Results

We recruited 895 patients with complete and quality control data. The median percentage

SUBMITTER: Wen X 

PROVIDER: S-EPMC9448012 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature