Metformin Use and Pancreatic Cancer Survival among Non-Hispanic White and African American U.S. Veterans with Diabetes Mellitus.

ABSTRACT:

Background

The effect of metformin use on survival among patients with pancreatic ductal adenocarcinoma (PDAC) is controversial. Furthermore, there are no data on African American patients. To address these, we analyzed data from the United States Veterans Health Administration (VHA).

Methods

A population-based retrospective cohort study evaluating overall survival among 3,811 patients with PDAC with preexisting diabetes mellitus, diagnosed with PDAC within the VHA between 1998 and 2013. We calculated HRs and 95% confidence intervals (CI) using multivariable adjusted time-varying Cox proportional hazards regression to control for immortal time bias and confounders.

Results

Metformin use was not associated with overall survival in the complete analyses (HR = 1.05; 95%

SUBMITTER: Toriola AT 

PROVIDER: S-EPMC9448292 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature