A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy.

ABSTRACT: Multinuclear muscle fibers are the most voluminous cells in skeletal muscle and the primary drivers of growth in response to loading. Outside the muscle fiber, however, is a diversity of mononuclear cell types that reside in the extracellular matrix (ECM). These muscle-resident cells are exercise-responsive and produce the scaffolding for successful myofibrillar growth. Without proper remodeling and maintenance of this ECM scaffolding, the ability to mount an appropriate response to resistance training in adult muscles is severely hindered. Complex cellular choreography takes place in muscles following a loading stimulus. These interactions have been recently revealed by single-cell explorations into muscle adaptation with loading. The intricate ballet of ECM remodeling involves collagen p

SUBMITTER: Brightwell CR 

PROVIDER: S-EPMC9448331 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature