Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration.

ABSTRACT:

Background

With the extensive development of intervertebral disc degeneration (IDD) research, IDD has been found to be a complex disease associated with immune-related gene (IRGs) changes. Nonetheless, the roles of IRGs in IDD are unclear.

Methods

In our study, 11 IRGs were chosen using differential analysis between nondisc degeneration and degenerative patients from the GEO database. Then, we utilized a random forest (RF) model to screen six candidate IRGs to predict the risk of IDD. A nomogram was developed on the basis of six candidate IRGs, and DCA showed that patients could benefit from the nomogram. Based on the selected significant IRGs, a consensus clustering approach was used to differentiate disc degeneration patients into two immune patterns (immune cluster A and

SUBMITTER: Wu B 

PROVIDER: S-EPMC9448583 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature