Urinary microbiome profile in men with genitourinary malignancies.

ABSTRACT:

Purpose

Recent advances in molecular biology technology have allowed identification of microbial communities in the urinary tract, and urinary microbiome is associated with various urological diseases. In this study, we aimed to characterize the urinary microbiome of genitourinary malignancies.

Materials and methods

Metagenomic analysis of urinary DNA was performed in 85 patients including 30 with bladder cancer (BC), 27 with prostate cancer (PC), 12 with renal cancer (RC), and 16 with non-cancer (NC). 16S rRNA gene sequencing was conducted after amplification of the V3-V4 region.

Results

PC and RC had significantly lower Shannon index than BC, and beta diversity showed significantly different microbiome composition between four groups. We identified six genera of

SUBMITTER: Ahn HK 

PROVIDER: S-EPMC9448674 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature