Tissue-wide cell-specific proteogenomic modeling reveals novel candidate risk genes in autism spectrum disorders.

ABSTRACT: Autism spectrum disorders (ASD) are a set of complex neurodevelopmental diseases characterized with repetitive behavioral patterns and communication disabilities. Using a systems biology method called MAPSD (Markov Affinity-based Proteogenomic Signal Diffusion) for joint modeling of proteome dynamics and a wide array of omics datasets, we identified a list of candidate ASD risk genes. Leveraging the collected biological signals as well as a large-scale protein-protein interaction network adjusted based on single cell resolution proteome properties in four brain regions, we observed an agreement between the known and the newly identified candidate genes that are spatially enriched in neuronal cells within cerebral cortex at the protein level. Moreover, we created a detailed subcellular loca

SUBMITTER: Doostparast Torshizi A 

PROVIDER: S-EPMC9448731 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature