The effect of the association between CETP variant type and alcohol consumption on cholesterol level differs according to the ALDH2 variant type.

ABSTRACT: Alcohol consumption is associated with a high increased lipid profile and this association may depend on genetic risk factors. In this study, we aimed to assess the effects of genetic variation associated with alcohol consumption on lipid profiles using data from two Korean population studies. We performed a genotype association study using the HEXA (n = 51,349) and KNHANES (n = 9158) data. Genotype analyses of the two sets of Korean population data showed associations of increased total cholesterol and high-density lipoprotein (HDL)-cholesterol with CETP rs708272. The HEXA and KNHANES populations revealed differences in HDL cholesterol according to the presence of CETP rs708272, independent of ALDH2 rs671 and alcohol consumption. In contrast, total cholesterol levels were associated with

SUBMITTER: Yoo MG 

PROVIDER: S-EPMC9448738 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature