MRI tractography reveals the human olfactory nerve map connecting the olfactory epithelium and olfactory bulb.

ABSTRACT: The olfactory nerve map describes the topographical neural connections between the olfactory epithelium in the nasal cavity and the olfactory bulb. Previous studies have constructed the olfactory nerve maps of rodents using histological analyses or transgenic animal models to investigate olfactory nerve pathways. However, the human olfactory nerve map remains unknown. Here, we demonstrate that high-field magnetic resonance imaging and diffusion tensor tractography can be used to visualize olfactory sensory neurons while maintaining their three-dimensional structures. This technique allowed us to evaluate the olfactory sensory neuron projections from the nasal cavities to the olfactory bulbs and visualize the olfactory nerve maps of humans, marmosets and mice. The olfactory nerve maps revea

SUBMITTER: Kurihara S 

PROVIDER: S-EPMC9448749 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature