STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer.
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ABSTRACT:
SUBMITTER: Pantelidou C
PROVIDER: S-EPMC9448789 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer.
Pantelidou Constantia C Jadhav Heta H Kothari Aditi A Liu Renyan R Wulf Gerburg M GM Guerriero Jennifer L JL Shapiro Geoffrey I GI
NPJ breast cancer 20220906 1
Poly (ADP-ribose) polymerase (PARP) inhibitors exert their efficacy via synthetic lethal effects and by inducing cGAS/STING-mediated immune responses. We demonstrate that compared to monotherapies, combined PARP inhibition and STING agonism results in increased STING pathway activation, greater cytotoxic T-cell recruitment and enhanced dendritic cell activation in BRCA1-deficient breast cancer models. The combination markedly improved anti-tumor efficacy in vivo, with evidence of complete tumor ...[more]
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