Transdiagnostic connectome signatures from resting-state fMRI predict individual-level intellectual capacity.

ABSTRACT: Medication and other therapies for psychiatric disorders show unsatisfying efficacy, in part due to the significant clinical/ biological heterogeneity within each disorder and our over-reliance on categorical clinical diagnoses. Alternatively, dimensional transdiagnostic studies have provided a promising pathway toward realizing personalized medicine and improved treatment outcomes. One factor that may influence response to psychiatric treatments is cognitive function, which is reflected in one's intellectual capacity. Intellectual capacity is also reflected in the organization and structure of intrinsic brain networks. Using a large transdiagnostic cohort (n = 1721), we sought to discover neuroimaging biomarkers by developing a resting-state functional connectome-based prediction model fo

SUBMITTER: Tong X 

PROVIDER: S-EPMC9448815 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature