Functional analysis of the RSC9 component of RSC chromatin remodeler reveals non-overlapping roles among the different subunits in C. albicans.

ABSTRACT: RSC (Remodel the Structure of Chromatin) chromatin remodeler in S. cerevisiae has multiple subunits, some of them are essential whereas the others are non-essential for cell viability. Not all the subunits are involved in all the functions of RSC complex. With several lines of evidences showing somewhat similar role of RSC complex [through Sth1 (Snf Two Homolog 1)] in different aspects of cell cycle (chromosome segregation and kinetochore function, etc.), DNA damage repair and stress response in C. albicans and S. cerevisiae, we hypothesize the organization of RSC complex in C. albicans could follow the same pattern as observed in S. cerevisiae. We hypothesize that the subset of the subunits could form different subcomplexes to do different biological fun

SUBMITTER: Prasad P 

PROVIDER: S-EPMC9448841 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature