Gene Expression Patterns of Osteopontin Isoforms and Integrins in Malignant Melanoma.

ABSTRACT: Osteopontin (OPN) is a multifunctional glycoprotein that physiologically interacts with different types of integrins. It is considered to be a possible prognostic biomarker in certain tumor types; however, various splicing isoforms exist, which have not been investigated in melanoma. We aimed to define the relative expression pattern of five OPN isoforms and clarify the prognostic significance of the splice variants in melanoma. We also aimed to investigate the expression pattern of eight integrins in the same tumors. Gene expression analyses revealed that the relative expression of OPNa, OPNb, and OPNc is significantly higher in metastatic tumors compared to primary lesions (p < 0.01), whereas the expression of OPN4 and OPN5 was low in both. The m

SUBMITTER: Jambor K 

PROVIDER: S-EPMC9448871 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature