Association between frontal fibrosing Alopecia and Rosacea: Results from clinical observational studies and gene expression profiles.

ABSTRACT:

Background

In recent years, frontal fibrosing alopecia (FFA), a type of scarring alopecia, has attracted increasing attention. Several studies have reported the frequent occurrence of rosacea in FFA; however, the association between FFA and rosacea and the underlying pathogenesis have not been thoroughly clarified. Thus, this study aimed to quantify these relationships and investigate their shared molecular mechanisms.

Methods

We evaluated the association between FFA and rosacea by analyzing clinical data from nine observational studies. We then analyzed the gene expression profiles of FFA and rosacea. First, differential expression analysis and weighted gene co-expression network analysis were used to identify the common differentially expressed genes (DEGs). Later, we cond

SUBMITTER: Liu L 

PROVIDER: S-EPMC9448884 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature