It takes two to tango: Widening our understanding of the onset of schizophrenia from a neuro-angiogenic perspective.

ABSTRACT: Schizophrenia is a chronic debilitating mental disorder characterized by perturbations in thinking, perception, and behavior, along with brain connectivity deficiencies, neurotransmitter dysfunctions, and loss of gray brain matter. To date, schizophrenia has no cure and pharmacological treatments are only partially efficacious, with about 30% of patients describing little to no improvement after treatment. As in most neurological disorders, the main descriptions of schizophrenia physiopathology have been focused on neural network deficiencies. However, to sustain proper neural activity in the brain, another, no less important network is operating: the vast, complex and fascinating vascular network. Increasing research has characterized schizophrenia as a systemic disease where vascular inv

SUBMITTER: Casas BS 

PROVIDER: S-EPMC9448889 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature