Estimating the causal effect of frailty index on vestibular disorders: A two-sample Mendelian randomization.

ABSTRACT:

Background

Frailty index and vestibular disorders appear to be associated in observational studies, but causality of the association remains unclear.

Methods

A two-sample Mendelian randomization (MR) study was implemented to explore the causal relationship between the frailty index and vestibular disorders in individuals of European descent. A genome-wide association study (GWAS) of frailty index was used as the exposure (n = 175, 226), whereas the GWAS of vestibular disorders was the outcome (n = 462,933). MR Steiger filtering method was conducted to investigate the causal effect of the frailty index on vestibular disorders. An inverse variance weighted (IVW) approach was used as the essential approach to examine the causality. Additionally, the MR-Egger metho

SUBMITTER: Xiao G 

PROVIDER: S-EPMC9448900 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature