Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategy.

ABSTRACT:

Background

Licensed vaccines against SARS-CoV-2 effectively protect against severe disease, but display incomplete protection against virus transmission. Mucosal vaccines providing immune responses in the upper airways are one strategy to protect against transmission.

Methods

We administered Spike HexaPro trimer formulated in a cationic liposomal adjuvant as a parenteral (subcutaneous - s.c.) prime - intranasal boost regimen to elicit airway mucosal immune responses and evaluated this in a Syrian hamster model of virus transmission.

Findings

Parenteral prime - intranasal boost elicited high-magnitude serum neutralizing antibody responses and IgA responses in the upper respiratory tract. The vaccine strategy protected against virus in the lower airways and lung patholo

SUBMITTER: Christensen D 

PROVIDER: S-EPMC9448948 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature