Identification of N7-methylguanosine related signature for prognosis and immunotherapy efficacy prediction in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is one of the most frequent causes of tumor-related mortality worldwide. Recently, the role of N7-methylguanosine (m⁷G) in tumors has begun to receive attention, but no investigation on the impact of m⁷G on LUAD. This study aims to elucidate the significance of m⁷G on the prognosis and immunotherapy in LUAD.

Methods

Consensus clustering was employed to determine the molecular subtype according to m⁷G-related regulators extracted from The Cancer Genome Atlas (TCGA) database. Survival, clinicopathological features and tumor mutational burden (TMB) analysis were applied to research molecular characteristics of each subtype. Subsequently, "limma" package was used to screen differentially expressed

SUBMITTER: Li Z 

PROVIDER: S-EPMC9449120 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature