Quantification of spatial subclonal interactions enhancing the invasive phenotype of pediatric glioma.

ABSTRACT: Diffuse midline gliomas (DMGs) are highly aggressive, incurable childhood brain tumors. They present a clinical challenge due to many factors, including heterogeneity and diffuse infiltration, complicating disease management. Recent studies have described the existence of subclonal populations that may co-operate to drive pro-tumorigenic processes such as cellular invasion. However, a precise quantification of subclonal interactions is lacking, a problem that extends to other cancers. In this study, we combine spatial computational modeling of cellular interactions during invasion with co-evolution experiments of clonally disassembled patient-derived DMG cells. We design a Bayesian inference framework to quantify spatial subclonal interactions between molecular and phenotypically distinct

SUBMITTER: Tari H 

PROVIDER: S-EPMC9449134 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature