Ontology highlight
ABSTRACT: Background/aims
The aim of this study was to investigate long-term post-discontinuation outcomes in patients with rheumatoid arthritis (RA) who had been treated with tumor necrosis factor-α inhibitors (TNF-αi) which was then discontinued.Methods
Sixty Korean patients with RA who participated in a 5-year GO-BEFORE and GO-FORWARD extension trials were included in this retrospective study. Golimumab was deliberately discontinued after the extension study (baseline). Patients were then followed by their rheumatologists. We reviewed their medical records for 2 years (max 28 months) following golimumab discontinuation. Patients were divided into a maintained benefit (MB) group and a loss-of-benefit (LB) group based on treatment pattern after golimumab discontinuation. The LB group included patients whose conventional disease-modifying antirheumatic drug(s) were stepped-up or added/switched (SC) and those who restarted biologic therapy (RB).Results
The mean age of patients at baseline was 56.5 years and 55 (91.7%) were females. At the end of follow-up, 23 (38.3%) patients remained in the MB group. In the LB group, 75.7% and 24.3% were assigned into SC and RB subgroups, respectively. Fifty percent of patients lost MB after 23.3 months. Demographics and clinical variables at baseline were comparable between MB and LB groups except for age, C-reactive protein level, and corticosteroid use. Restarting biologic therapy was associated with swollen joint count (adjusted hazard ratio [HR], 1.90; 95% confidence interval [CI], 1.01 to 3.55) and disease duration (adjusted HR, 1.12; 95% CI, 1.02 to 1.23) at baseline.Conclusion
Treatment strategies after discontinuing TNF-αi are needed to better maintain disease control and quality of life of patients with RA.
SUBMITTER: Shin K
PROVIDER: S-EPMC9449209 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Shin Kichul K Kwon Hyun Mi HM Kim Min Jung MJ Yoon Myung Jae MJ Chai Hyun Gyung HG Kang Seong-Wook SW Park Won W Park Sung-Hwan SH Suh Chang Hee CH Kim Hyun Ah HA Lee Seung-Geun SG Lee Choong Ki CK Bae Sang-Cheol SC Park Yong-Beom YB Song Yeong Wook YW
The Korean journal of internal medicine 20211213 5
<h4>Background/aims</h4>The aim of this study was to investigate long-term post-discontinuation outcomes in patients with rheumatoid arthritis (RA) who had been treated with tumor necrosis factor-α inhibitors (TNF-αi) which was then discontinued.<h4>Methods</h4>Sixty Korean patients with RA who participated in a 5-year GO-BEFORE and GO-FORWARD extension trials were included in this retrospective study. Golimumab was deliberately discontinued after the extension study (baseline). Patients were th ...[more]