Identification of key genes involved in nasopharyngeal carcinoma.

ABSTRACT:

Introduction

Nasopharyngeal carcinoma is the most common cancer originating from the nasopharynx.

Objective

To study the mechanisms of nasopharyngeal carcinoma, we analyzed GSE12452 microarray data.

Methods

GSE12452 was downloaded from the Gene Expression Omnibus database and included 31 nasopharyngeal carcinoma samples and 10 normal nasopharyngeal tissue samples. The differentially expressed genes were screened by ANOVA in the PGS package. Using the BiNGO plugin in Cytoscape and pathway enrichment analysis in the PGS package, functional and pathway enrichment analyses were performed separately to predict potential functions of the differentially expressed genes. Furthermore, Transcription factor-differentially expressed gene pairs were searched, and then the transcri

SUBMITTER: Jiang X 

PROVIDER: S-EPMC9449222 | biostudies-literature | 2017 Nov - Dec

REPOSITORIES: biostudies-literature