Emerging roles of mesenchymal stem cell therapy in patients with critical limb ischemia.

ABSTRACT: Critical limb ischemia (CLI), the terminal stage of peripheral arterial disease (PAD), is characterized by an extremely high risk of amputation and vascular issues, resulting in severe morbidity and mortality. In patients with severe limb ischemia with no alternative therapy options, such as endovascular angioplasty or bypass surgery, therapeutic angiogenesis utilizing cell-based therapies is vital for increasing blood flow to ischemic regions. Mesenchymal stem cells (MSCs) are currently considered one of the most encouraging cells as a regenerative alternative for the surgical treatment of CLI, including restoring tissue function and repairing ischemic tissue via immunomodulation and angiogenesis. The regenerative treatments for limb ischemia based on MSC therapy are still considered expe

SUBMITTER: Shirbaghaee Z 

PROVIDER: S-EPMC9449296 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature