Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial.

ABSTRACT:

Objective

To determine if daily supplementation with cod liver oil, a low dose vitamin D supplement, in winter, prevents SARS-CoV-2 infection, serious covid-19, or other acute respiratory infections in adults in Norway.

Design

Quadruple blinded, randomised placebo controlled trial.

Setting

Norway, 10 November 2020 to 2 June 2021.

Participants

34 601 adults (aged 18-75 years), not taking daily vitamin D supplements.

Intervention

5 mL/day of cod liver oil (10 µg of vitamin D, n=17 278) or placebo (n=17 323) for up to six months.

Main outcome measures

Four co-primary endpoints were predefined: the first was a positive SARS-CoV-2 test result determined by reverse transcriptase-quantitative polymerase chain reaction and the second was serious covid-19,

SUBMITTER: Brunvoll SH 

PROVIDER: S-EPMC9449357 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature