Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma.

ABSTRACT: Background: Increasing evidence supports that lactate plays an important role in tumor proliferation, invasion and within the tumor microenvironment (TME). This is particularly relevant in lung adenocarcinoma (LUAD). Therefore, there is a current need to investigate lactate metabolism in LUAD patients and how lactate metabolism is affected by different therapies. Methods: Data from LUAD patients were collected from The Cancer Genome Atlas (TCGA) and patients were divided into two subtypes according to 12 lactate metabolism-related genes to explore the effect of lactate metabolism in LUAD. We established a lactate-related prognostic indicator (LRPI) based on different gene expression profiles. Subsequently, we investigated associations between this LRPI and patient survival, m

SUBMITTER: Chang X 

PROVIDER: S-EPMC9449370 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature