Genomic insights from Paraclostridium bifermentans HD0315_2: General features and pathogenic potential.

ABSTRACT:

Background

Paraclostridium bifermentans is the most diverse distributed species of Paraclostridium and can cause fatal human infections under rare conditions. However, its pathogenic mechanisms and adaptation ability behind infections remain unclear. Herein, we reported the complete genome sequence of P. bifermentans HD0315_2 isolated from the feces of a patient with Crohn's disease. Then, we performed genomic analyses to understand its pathogenic mechanisms and adaptation ability.

Results

The de novo assembly revealed that the HD0315_2 strain carried a circular chromosome of 3.27 Mb and six circular plasmids (19.41 to 139.50 kb). The phylogenomic analysis assigned the HD0315_2 strain as P. bifermentans and reclassified some previously non-

SUBMITTER: Zhao H 

PROVIDER: S-EPMC9449513 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature