Cortical bone relationships are maintained regardless of sex and diet in a large population of LGXSM advanced intercross mice.

ABSTRACT:

Introduction

Knowledge of bone structure-function relationships in mice has been based on relatively small sample sets that limit generalizability. We sought to investigate structure-function relationships of long bones from a large population of genetically diverse mice. Therefore, we analyzed previously published data from the femur and radius of male and female mice from the F34 generation of the Large-by-Small advanced intercross line (LGXSM AI), which have over a two-fold continuous spread of bone and body sizes (Silva et al. 2019 JBMR).

Methods

Morphological traits, mechanical properties, and estimated material properties were collected from the femur and radius from 1113 LGXSM AI adult mice (avg. age 25 wks). Males and females fed a low-fat or high-fat diet were evalu

SUBMITTER: Migotsky N 

PROVIDER: S-EPMC9449555 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature