Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.

ABSTRACT: Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the lamina propria (LP) of patients with ulcerative colitis (UC) and Crohn's disease (CD), we observed an enrichment of CD4⁺ effector T cells producing IL-17A and TNF, CD8⁺ T cells producing IFNγ, T regulatory (Treg) cells, and innate lymphoid cells (ILC). The function of these immune cells is regulated by store-operated Ca²⁺ entry (SOCE), which results from the opening of Ca²⁺ release-activated Ca²⁺ (CRAC) channels formed by ORAI and STIM proteins. We observed that the pharmacologic inhibition of SOCE attenuated the production of proinflammatory cytokines including IL-2,

SUBMITTER: Letizia M 

PROVIDER: S-EPMC9449601 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature