Platelet reactivity after clopidogrel loading in patients with acute ischemic stroke.

ABSTRACT:

Objective

It remains unclear when sufficient antiplatelet effect is achieved after administration of a loading dose of clopidogrel in patients with acute ischemic stroke (AIS). This study aimed to evaluate the clopidogrel response in patients with AIS identified by the platelet function test (PFT).

Methods

P2Y₁₂ reaction unit (PRU) values measured using VerifyNow at baseline and at 6, 24, and 72 h after administration of a loading dose (300 mg) of clopidogrel were compared between patients with AIS and those of other cerebrovascular diseases (CVD). The prevalence of clopidogrel abnormal response and its associated factors were examined.

Results

The PRU value was significantly reduced with time in the other CVD group (p < 0.0001), and also in the AIS

SUBMITTER: Enomoto Y 

PROVIDER: S-EPMC9449631 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature