Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder.

ABSTRACT: Early life stress (ELS) and major depressive disorder (MDD) share neural network abnormalities. However, it is unclear how ELS and MDD may separately and/or jointly relate to brain networks, and whether neural differences exist between depressed individuals with vs without ELS. Moreover, prior work evaluated static versus dynamic network properties, a critical gap considering brain networks show changes in coordinated activity over time. Seventy-one unmedicated females with and without childhood sexual abuse (CSA) histories and/or MDD completed a resting state scan and a stress task in which cortisol and affective ratings were collected. Recurring functional network co-activation patterns (CAPs) were examined and time in CAP (number of times each CAP is expressed) and transition frequencie

SUBMITTER: Belleau EL 

PROVIDER: S-EPMC9449675 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature