A touchscreen-based paradigm to measure visual pattern separation and pattern completion in mice.

ABSTRACT: Memory accuracy involves two major processes: pattern separation and pattern completion. Pattern separation refers to the ability to reduce overlap among similar inputs to avoid interference, and pattern completion refers to the ability to retrieve the whole information from partial or degraded cues. Impairments in pattern separation/pattern completion contribute to cognitive deficits in several diseases of the nervous system. Therefore, it is better to evaluate both pattern separation and pattern completion in one apparatus. However, few tools are available to assess pattern separation and pattern completion within the same apparatus for rodents. In this study, we designed a series of images with varying degrees of similarity to the correct image to evaluate pattern separation and pattern

SUBMITTER: Wang H 

PROVIDER: S-EPMC9449699 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature