Association of Unhealthy Lifestyle and Childhood Adversity With Acceleration of Aging Among UK Biobank Participants.

ABSTRACT:

Importance

Accelerated aging makes adults more vulnerable to chronic diseases and death. Whether childhood adversity is associated with accelerated aging processes, and to what extent lifestyle mediates the association, remain unknown.

Objective

To examine the associations of childhood adversity with a phenotypic aging measure and the role of unhealthy lifestyle in mediating these associations.

Design, setting, and participants

A retrospective cohort analysis was conducted using data from adult participants in the UK Biobank baseline survey (2006-2010) and online mental health survey (2016). Data analysis was performed from September 1, 2021, to February 28, 2022.

Exposures

Childhood adversity, including physical neglect, emotional neglect, sexual abuse, physic

SUBMITTER: Yang G 

PROVIDER: S-EPMC9449787 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature