Detection of clonal mast cell disease in wasp venom allergic patients with normal tryptase.

ABSTRACT:

Background

Clonal mast cell disease (CMD) is an underlying aggravating condition in wasp venom allergy (WVA) which requires a different treatment strategy. CMD is increasingly recognized in patients with normal basal serum tryptase (bsT). However, methods to identify at risk patients have not yet been assessed in large cohorts of WVA patients with normal bsT.

Methods

This retrospective study evaluated the reliability of the REMA score in detecting CMD in a cohort of grade IV WVA patients with normal bsT and assessed the added value of other clinical parameters, KIT D816V mutation analysis in peripheral blood (PB) and the diagnosis of hereditary alpha tryptasemia (HAT). All patients had a conclusive bone marrow evaluation that demonstrated or excluded underlying CMD.

SUBMITTER: Onnes MC 

PROVIDER: S-EPMC9449818 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature