Mechanisms and Extent of Enhanced Passive Permeation by Colloidal Drug Particles.

ABSTRACT: Formulations containing nanosized drug particles such as nanocrystals and nanosized amorphous drug aggregates recently came into light as promising strategies to improve the bioavailability of poorly soluble drugs. However, the increased solubility due to the reduction in particle size cannot adequately explain the enhanced bioavailability. In this study, the mechanisms and extent of enhanced passive permeation by drug particles were investigated using atazanavir, lopinavir, and clotrimazole as model drugs. Franz diffusion cells with lipid-infused membranes were utilized to evaluate transmembrane flux. The impact of stirring rate, receiver buffer condition, and particle size was investigated, and mass transport analyses were conducted to calculate transmembrane flux. Flux enhancement by pa

SUBMITTER: Narula A 

PROVIDER: S-EPMC9449982 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature