Genetic Association between Interleukin Genes and Alopecia Areata in Jordanian Patients.

ABSTRACT:

Objectives

Alopecia areata (AA) is a multifactorial autoimmune disease with a strong genetic predisposition. A variety of genes involved in immunity and inflammatory responses, such as cytokines, are suspected to increase the risk of developing AA. In which, different interleukin (IL) genes that associated with several autoimmune diseases and AA in varied populations. The objective of this study was to investigate the possible genetic association of AA with ten variants of single nucleotide polymorphism (SNP) in IL12B,IL13,IL16,IL17A, and IL18 genes among Jordanian patients.

Methods

In this case-control study, peripheral blood samples of 152 Jordanian AA patients and 150 controls (total of 302 subjects) were collected, genomic DNA extracted and genotyped, based

SUBMITTER: Eitan LNA 

PROVIDER: S-EPMC9449993 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature