Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson's disease.

ABSTRACT: The pathological hallmarks of Parkinson's disease (PD) are α-synuclein (αSYN)-positive inclusions referred to as Lewy bodies and Lewy neurites, collectively referred to as Lewy-related pathology (LRP). LRP is thought to propagate in an ascending manner throughout the brain as the disease progresses. LRP is visible with histologic methods and is thought to represent a later stage of the disease process, while αSYN oligomers, which are not visible with routine histologic methods, are considered earlier. There is increasing evidence to suggest that αSYN oligomers may be more toxic than visible LRP. Detecting αSYN oligomers requires special techniques, and their distribution and association with clinical features are important research objectives. In this report, we describe the distribution o

SUBMITTER: Sekiya H 

PROVIDER: S-EPMC9450240 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature