Haptoglobin is an early indicator of survival after radiation-induced severe injury and bone marrow transplantation in mice.

ABSTRACT:

Background

Hematopoietic stem cell transplantation (HSCT) is the main treatment for acute radiation sickness, especially after fatal radiation. The determination of HSCT for radiation patients is mainly based on radiation dose, hemogram and bone marrow injury severity. This study aims to explore a better biomarker of acute radiation injury from the perspective of systemic immune response.

Methods

C57BL/6J female mice were exposed to total body irradiation (TBI) and partial body irradiation (PBI). Changes in haptoglobin (Hp) level in plasma were shown at different doses and time points after the exposure and treatment with amifostine or bone marrow transplantation. Student's t-test/two tailed test were used in two groups. To decide the Hp levels as a predictor of the radiatio

SUBMITTER: Zhou S 

PROVIDER: S-EPMC9450283 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature