Connective tissue growth factor promotes cementogenesis and cementum repair via Cx43/β-catenin axis.

ABSTRACT:

Background

Orthodontic tooth movement inevitably induces cementum resorption, which is an urgent problem for orthodontists to confront. Human periodontal ligament stem cells (hPDLSCs) exert an important role in the orthodontic tooth movement and exhibit multidirectional differentiation ability in cementum regeneration. Connective tissue growth factor (CTGF) is an important extracellular matrix protein for bone homeostasis and cell differentiation. The purpose of our study was to explore the role of CTGF in cementum repair and cementogenesis and to elucidate its underlying mechanism.

Methods

A cementum defect model was established by tooth movement with heavy forces, and the cementum repair effect of CTGF was observed via micro-CT, HE staining and immunohistochemical staining

SUBMITTER: Wu Z 

PROVIDER: S-EPMC9450312 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature