Linking cerebellar functional gradients to transdiagnostic behavioral dimensions of psychopathology.

ABSTRACT: High co-morbidity and substantial overlap across psychiatric disorders encourage a transition in psychiatry research from categorical to dimensional approaches that integrate neuroscience and psychopathology. Converging evidence suggests that the cerebellum is involved in a wide range of cognitive functions and mental disorders. An important question thus centers on the extent to which cerebellar function can be linked to transdiagnostic dimensions of psychopathology. To address this question, we used a multivariate data-driven statistical technique (partial least squares) to identify latent dimensions linking human cerebellar connectome as assessed by functional MRI to a large set of clinical, cognitive, and trait measures across 198 participants, including healthy controls (n = 92) as we

SUBMITTER: Dong D 

PROVIDER: S-EPMC9450332 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature