Renal outcomes according to renal replacement therapy modality and treatment protocol in the ATN and RENAL trials.

ABSTRACT:

Background

In critically ill patients with acute kidney injury, renal replacement therapy (RRT) modality and treatment protocols may affect kidney recovery. This study explored whether RRT modality and treatment protocol affected RRT dependence in the 'Randomized Evaluation of Normal versus Augmented Level of RRT' and the 'Acute Renal Failure Trial Network' (ATN) trials.

Methods

Primary outcome was 28-day RRT dependence. Secondary outcomes included RRT dependence among survivors and in different SOFA-based treatment protocol groups. We used the Fine-Gray competing-risk model sub-distribution hazard ratio (SHR) to assess the primary outcome. Analyses were adjusted for confounders.

Results

Of 2542 patients, 2175 (85.5%) received continuous RRT (CRRT) and 367 (14.4%) rec

SUBMITTER: Naorungroj T 

PROVIDER: S-EPMC9450407 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature