Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits.

ABSTRACT:

Background

Apnea of prematurity (AOP) is caused by respiratory control immaturity and affects nearly 50% of premature newborns. This pathology induces perinatal intermittent hypoxia (IH), which leads to neurodevelopmental disorders. The impact on the brain has been well investigated. However, despite its functional importance and immaturity at birth, the involvement of the cerebellum remains poorly understood. Therefore, this study aims to identify the effects of IH on cerebellar development using a mouse model of AOP consisting of repeated 2-min cycles of hypoxia and reoxygenation over 6 h and for 10 days starting on postnatal day 2 (P2).

Results

At P12, IH-mice cerebella present higher oxidative stress associated with delayed maturation of the cerebellar cortex and decreas

SUBMITTER: Leroux S 

PROVIDER: S-EPMC9450451 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature