Robust pyroptosis risk score guides the treatment options and predicts the prognosis of bladder carcinoma.

ABSTRACT:

Background

Bladder carcinoma (BLCA) is a heterogeneous disease that makes it difficult to achieve proper individual treatment and predict prognosis. This study aimed to develop a risk score from a new perspective of pyroptosis and guide accurate treatment and prognosis prediction for BLCA.

Methods

The TCGA-BLCA cohort data were downloaded from The Cancer Genome Atlas database. Two external validation cohorts were collected from the Gene Expression Omnibus. Another independent validation cohort (the Xiangya cohort) was recruited from our hospital. The least absolute shrinkage and selector operation (LASSO) algorithm and Cox regression models were used to establish the pyroptosis risk score. Thereafter, we correlated the pyroptosis risk score with prognosis, tumor microenviron

SUBMITTER: Deng D 

PROVIDER: S-EPMC9450692 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature