Gut microbiota mediates the inhibition of lymphopoiesis in dietary-restricted mice by suppressing glycolysis.

ABSTRACT: Dietary restriction (DR) is one of the most robust interventions shown to extend health-span and remains on the forefront of anti-aging intervention studies, though conflicting results have been shown on its effect on lifespan both in rodents and primates. The severe inhibitory effects on the lymphoid lineage by DR remains one of its major negative downsides which reduces its overall beneficial effects on organismal health. Yet, the underlying mechanism of how DR suppresses the lymphoid system remains to be explored. Here, we show that antibiotic ablation of gut microbiota significantly rescued the inhibition of lymphopoiesis by DR. Interestingly, glycolysis in lymphocytes was significantly down-regulated in DR mice and pharmacological inhibition of glycolysis reverted this rescue effect o

SUBMITTER: Tao S 

PROVIDER: S-EPMC9450896 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature