Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic life-long inflammatory disease affecting almost 2 million Americans. Although new biologic therapies have been developed, the standard medical treatment fails to selectively control the dysregulated immune pathways involved in chronic colonic inflammation. Further, IBD patients with uncontrolled colonic inflammation are at a higher risk for developing colorectal cancer (CRC). Intestinal microbes can impact many immune functions, and here we asked if they could be used to improve intestinal inflammation. By utilizing an intestinal adherent E. coli that we find increases IL-10 producing macrophages, we were able to limit intestinal inflammation and restrict tumor formation. Macrophage IL-10 along with IL-10 signaling to the intestinal epit

SUBMITTER: Zegarra Ruiz DF 

PROVIDER: S-EPMC9450902 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature