Bezlotoxumab prevents extraintestinal organ damage induced by Clostridioides difficile infection.

ABSTRACT: Clostridioides difficile is the most common cause of infectious antibiotic-associated diarrhea, with disease mediated by two major toxins TcdA and TcdB. In severe cases, systemic disease complications may arise, resulting in fatal disease. Systemic disease in animal models has been described, with thymic damage an observable consequence of severe disease in mice. Using a mouse model of C. difficile infection, we examined this disease phenotype, focussing on the thymus and serum markers of systemic disease. The efficacy of bezlotoxumab, a monoclonal TcdB therapeutic, to prevent toxin mediated systemic disease complications was also examined. C. difficile infection causes toxin-dependent thymic damage and CD4⁺CD8⁺ thymocyte depletion in mice. These

SUBMITTER: Mileto SJ 

PROVIDER: S-EPMC9450906 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature