Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor.

ABSTRACT:

Background

Wilms tumor is the most common childhood kidney cancer. Two distinct histological subtypes of Wilms tumor have been described: tumors lacking anaplasia (the favorable subtype) and tumors displaying anaplastic features (the unfavorable subtype). Children with favorable disease generally have a very good prognosis, whereas those with anaplasia are oftentimes refractory to standard treatments and suffer poor outcomes, leading to an unmet clinical need. MYCN dysregulation has been associated with a number of pediatric cancers including Wilms tumor.

Procedures

In this context, we undertook a functional genomics approach to uncover novel therapeutic strategies for those patients with anaplastic Wilms tumor. Genomic analysis and in vitro experimentation demonstrate that

SUBMITTER: Woods AD 

PROVIDER: S-EPMC9450910 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature