HYPK coordinates degradation of polyneddylated proteins by autophagy.
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ABSTRACT:
SUBMITTER: Ghosh DK
PROVIDER: S-EPMC9450979 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
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HYPK coordinates degradation of polyneddylated proteins by autophagy.
Ghosh Debasish Kumar DK Ranjan Akash A
Autophagy 20211126 8
Selective degradation of protein aggregates by macroautophagy/autophagy is an essential homeostatic process of safeguarding cells from the effects of proteotoxicity. Among the ubiquitin-like proteins, NEDD8 conjugation to misfolded proteins is prominent in stress-induced protein aggregates, albeit the function of neddylation in autophagy is unclear. Here, we report that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein ...[more]
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