Incubation of cocaine craving coincides with changes in dopamine terminal neurotransmission.

ABSTRACT: Relapse to drug use is one of the major challenges in treating substance use disorders. Exposure to drug-related cues and contexts triggers drug craving, which drives cocaine seeking, and increases the probability of relapse. Clinical and animal studies have shown a progressive intensification of cocaine seeking and craving that develops over the course of abstinence, a phenomenon commonly referred to as incubation of cocaine craving. Although the neurobiology underlying incubation of cocaine craving has been examined - particularly within the context of glutamate plasticity- the extent to which increased cocaine craving engenders mesolimbic dopamine (DA) changes has received relatively little attention. To assess whether incubation of cocaine craving is associated with alterations in DA t

SUBMITTER: Alonso IP 

PROVIDER: S-EPMC9451023 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature