Interferon-γ promotes monocyte-mediated lung injury during influenza infection.

ABSTRACT: Influenza A virus (IAV) infection triggers an exuberant host response that promotes acute lung injury. However, the host response factors that promote the development of a pathologic inflammatory response to IAV remain incompletely understood. In this study, we identify an interferon-γ (IFN-γ)-regulated subset of monocytes, CCR2⁺ monocytes, as a driver of lung damage during IAV infection. IFN-γ regulates the recruitment and inflammatory phenotype of CCR2⁺ monocytes, and mice deficient in CCR2 (CCR2^-/-) or IFN-γ (IFN-γ^-/-) exhibit reduced lung inflammation, pathology, and disease severity. Adoptive transfer of wild-type (WT) (IFN-γR1^+/+) but not IFN-γR1^-/- CCR2⁺ monocytes restore the WT-like pathological phenotype

SUBMITTER: Schmit T 

PROVIDER: S-EPMC9451105 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature