Early molecular markers of ventilator-associated pneumonia in bronchoalveolar lavage in preterm infants.

ABSTRACT:

Introduction

Ventilator-associated pneumonia (VAP) constitutes a serious nosocomial infection. Our aim was to evaluate the reliability of cytokines and oxidative stress/inflammation biomarkers in bronchoalveolar lavage fluid (BALF) and tracheal aspirates (TA) as early biomarkers of VAP in preterm infants.

Methods

Two cohorts were enrolled, one to select candidates and the other for validation. In both, we included preterms with suspected VAP, according to BALF culture, they were classified into confirmed VAP and no VAP. Concentration of 16 cytokines and 8 oxidative stress/inflammation biomarkers in BALF and TA was determined in all patients.

Results

In the first batch, IL-17A and TNF-α in BALF, and in the second one IL-10, IL-6, and TNF-α in BALF were significantly hi

SUBMITTER: Pinilla-Gonzalez A 

PROVIDER: S-EPMC9451119 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature